B.Pharmacy Pharmaceutical Organic Chemistry 1 Notes

B.Pharmacy 2nd Semester Pharmaceutical Organic Chemistry-1 notes cover classification, nomenclature, and isomerism of organic compounds. The syllabus includes alkanes, alkenes, conjugated dienes, alkyl halides, alcohols, aldehydes, ketones, carboxylic acids, and aliphatic amines. Key topics such as substitution and elimination reactions, condensation reactions, hybridization, qualitative tests, and the structures and pharmaceutical uses of important compounds provide a complete foundation for pharmacy students.

Bachelor of Pharmacy
Semester		2nd Semester		Subject		Pharmaceutical Organic Chemistry
Syllabus
Unit 1st	Classification, nomenclature and isomerism Classification of Organic Compounds Common and IUPAC systems of nomenclature of organic compounds (up to 10 Carbons open chain and carbocyclic compounds) Structural isomerisms in organic compounds
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Unit 2nd	Alkanes, Alkenes and Conjugated dienes SP3 hybridization in alkanes, Halogenation of alkanes, uses of paraffins. Stabilities of alkenes, SP2 hybridization in alkenes E1 and E2 reactions– kinetics, order of reactivity of alkyl halides, rearrangement of carbocations, Saytzeffs orientation and evidences. E1 verses E2 reactions, Factors affecting E1 and E2 reactions. Ozonolysis, electrophilic addition reactions of alkenes, Markownikoff’s orientation, free radical addition reactions of alkenes, Anti Markownikoff’s orientation. Stability of conjugated dienes, Diel-Alder, electrophilic addition, free radical addition reactions of conjugated dienes, allylic rearrangement
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Unit 3rd	Alkylhalides SN1 and SN2 reactions- kinetics, order of reactivity of alkyl halides, stereochemistry and rearrangement of carbocations. SN1 versus SN2 reactions, Factors affecting SN1 and SN2 reactions Structure and uses of ethylchloride, Chloroform, trichloroethylene, tetrachloroethylene, dichloromethane, tetrachloromethane and iodoform. Alcohols Qualitative tests, Structure and uses of Ethyl alcohol, Methyl alcohol, chlorobutanol, Cetosteryl alcohol, Benzyl alcohol, Glycerol, Propylene glycol
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Unit 4th	Carbonyl compounds (Aldehydes and ketones) Nucleophilic addition, Electromeric effect, aldol condensation, Crossed Aldol condensation, Cannizzaro reaction, Crossed Cannizzaro reaction, Benzoin condensation, Perkin condensation, qualitative tests, Structure and uses of Formaldehyde, Paraldehyde, Acetone, Chloral hydrate, Hexamine, Benzaldehyde, Vanilin, Cinnamaldehyde.
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Unit 5th	Carboxylic acids Acidity of carboxylic acids, effect of substituents on acidity, inductive effect and qualitative tests for carboxylic acids ,amide and ester Structure and Uses of Acetic acid, Lactic acid, Tartaric acid, Citric acid, Succinic acid. Oxalic acid, Salicylic acid, Benzoic acid, Benzyl benzoate, Dimethyl phthalate, Methyl salicylate and Acetyl salicylic acid Aliphatic amines Basicity, effect of substituent on Basicity. Qualitative test, Structure and uses of Ethanolamine, Ethylenediamine, Amphetamine
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Pharmaceutical Organic Chemistry-1 for B.Pharmacy 2nd semester covers the classification, nomenclature, and isomerism of organic compounds, providing a foundation for systematic understanding. It explains the chemistry and reactions of alkanes, alkenes, conjugated dienes, alkyl halides, alcohols, aldehydes, ketones, carboxylic acids, and aliphatic amines. Key topics include substitution and elimination reactions, condensation reactions, hybridization, qualitative tests, and the structures and pharmaceutical uses of important organic compounds, offering a comprehensive understanding for pharmaceutical applications.

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