B.Pharmacy 3rd Semester Physical Pharmaceutics 1 Notes

Physical Pharmaceutics–I notes for B.Pharmacy 3rd semester cover essential concepts of states of matter, solubility, dissolution, surface and interfacial phenomena, micromeritics, and rheology. These notes help students understand physicochemical principles applied in drug formulation, stability, bioavailability, and pharmaceutical dosage form design.

Bachelor of Pharmacy
Semester		3rd Semester		Subject		Physical Pharmaceutics 1
Syllabus
Unit 1st	Solubility of drugs: Solubility expressions, mechanisms of solute-solvent interactions, ideal solubility parameters, solvation & association, a quantitative approach to the factors influencing solubility of drugs, and diffusion principles in biological systems. Solubility of gas in liquids, solubility of liquids in liquids (binary solutions, ideal solutions) Raoult’s law, real solutions. Partially miscible liquids, Critical solution temperature and applications. Distribution law, its limitations and applications
Click Here
Unit 2nd	States of matter and properties of matter: State of matter, changes in the state of matter, latent heats, vapour pressure, sublimation critical point, eutectic mixtures, gases, aerosols–inhalers, relative humidity, liquid complexes, liquid crystals, glassy states, solid crystalline, amorphous & polymorphism. Physicochemical properties of drug molecules: Refractive index, optical rotation, dielectric constant, dipole moment, dissociation constant, determinations and applications
Click Here
Unit 3rd	Surface and interfacial phenomenon: Liquid interface, surface & interfacial tensions, surface free energy, measurement of surface & interfacial tensions, spreading coefficient, adsorption at liquid interfaces, surface-active agents, HLB scale, solubilisation, detergency, and adsorption at solid interfaces.
Click Here
Unit 4th	Complexation and protein binding: Introduction, classification of complexation, applications, methods of analysis, protein binding, complexation and drug action, crystalline structures of complexes and thermodynamic treatment of stability constants.
Click Here
Unit 5th	pH, buffers and Isotonic solutions: Sorensen’s pH scale, pH determination (electrometric and calorimetric), applications of buffers, buffer equation, buffer capacity, buffers in pharmaceutical and biological systems, buffered isotonic solutions
Click Here

Physical Pharmaceutics–I deals with the fundamental physical and physicochemical principles applied in pharmacy. It covers states of matter, intermolecular forces, solubility, dissolution, surface and interfacial phenomena, rheology, and micromeritics. The subject explains how these principles influence drug formulation, stability, bioavailability, and dosage form design, forming a strong base for pharmaceutics and industrial pharmacy studies.

• First of all visit the website carewellpharma.shop
• After that select semester in B.Pharma
• And then select the subject
• After that you will get the download button, save it from there.

Home