Are you a B.Pharmacy 5th semester student looking for complete and easy-to-understand notes on Medicinal Chemistry–II? You’re in the right place! Here you can download PDF notes that cover the entire syllabus as per the PCI guidelines, including chemical structures, SAR, mechanisms of action, and classification of drugs.
Introduction
Subject Name: Medicinal Chemistry–II
Semester: 5th Semester
Course: B.Pharmacy
📚 Unit‑Wise PCI Syllabus
Unit I – Antihistaminic Agents, Anti‑cancer & PPIs
- Histamine & Receptors
- H₁ Antagonists: Diphenhydramine HCl, Dimenhydrinate, Doxylamine succinate, Clemastine fumarate, Chlorcyclizine HCl, Meclizine HCl, Buclizine HCl, Chlorpheniramine maleate, Triprolidine HCl, Promethazine HCl, Cyproheptadine HCl, Azatidine maleate, Astemizole, Loratadine, Cetirizine, Levocetirizine, Cromolyn sodium
- H₂ Antagonists: Cimetidine, Famotidine, Ranitidine
- Proton Pump Inhibitors (PPIs): Omeprazole, Lansoprazole, Rabeprazole, Pantoprazole
- Anti‑neoplastic Agents: Alkylating agents (Mechlorethamine, Cyclophosphamide, Melphalan, Chlorambucil, Busulfan, Thiotepa), Antimetabolites (Mercaptopurine, Thioguanine, Fluorouracil, Floxuridine, Cytarabine, Methotrexate, Azathioprine), Antibiotics (Dactinomycin, Daunorubicin, Doxorubicin, Bleomycin), Plant products (Etoposide, Vinblastine, Vincristine), Miscellaneous (Cisplatin, Mitotane)
Unit II – Cardiovascular & Related Agents
- Anti‑Anginal / Vasodilators: Amyl nitrite, Nitroglycerin, Pentaerythritol tetranitrate, Isosorbide dinitrite, Dipyridamole
- Anti‑hypertensives / Diuretics / Lipid Regulators: Calcium channel blockers (Verapamil, Diltiazem, Nifedipine, Amlodipine, Felodipine, Nicardipine, Nimodipine), Diuretics (Acetazolamide, Hydrochlorothiazide, Furosemide, Spironolactone, Mannitol, etc.), ACE inhibitors (Captopril, Lisinopril, Enalapril), Clonidine, Reserpine, Hydralazine
- Anti‑arrhythmics: Quinidine, Procainamide, Lidocaine, Amiodarone, Sotalol, Disopyramide, Mexiletine, Phenytoin
- Anti‑hyperlipidemics & Coagulants: Clofibrate, Lovastatin, Cholestyramine, Warfarin, Clopidogrel, Menadione, Digoxin, Bosentan, Nesiritide
Unit III
Anti-arrhythmic Drugs: Quinidine sulphate, Procainamide hydrochloride, Disopyramide phosphate, Phenytoin sodium, Lidocaine hydrochloride, Tocainide hydrochloride, Mexiletine hydrochloride, Lorcainide hydrochloride, Amiodarone,Sotalol.
Anti-hyperlipidemic agents: Clofibrate, Lovastatin, Cholesteramine and Cholestipol
Coagulant & Anticoagulants: Menadione, Acetomenadione, Warfarin, Anisindione,clopidogrel
Drugs used in Congestive Heart Failure: Digoxin, Digitoxin, Nesiritide, Bosentan,Tezosentan.
Unit IV – Endocrine, Sex Hormones & Local Anesthetics
- Endocrine & Steroid Drugs: Nomenclature, stereochemistry, metabolism
- Sex Hormones: Testosterone, Nandrolone, Progestogens, Estriol, Estradiol, Diethylstilbestrol
- Drugs for Erectile Dysfunction: Sildenafil, Tadalafil
- Oral Contraceptives: Mifepristone, Levonorgestrel, Norgestril
- Corticosteroids: Prednisolone, Betamethasone, Hydrocortisone, Dexamethasone
- Thyroid & Antithyroid Drugs: L‑Thyroxine, Propylthiouracil, Methimazole
Unit V – Antidiabetics & Local Anesthetics
- Antidiabetic Agents: Insulin preparations, Sulfonylureas (Tolbutamide, Glipizide, Glimepiride), Biguanides (Metformin), Thiazolidinediones (Pioglitazone, Rosiglitazone), Meglitinides (Repaglinide, Nateglinide), Glucosidase inhibitors (Acarbose, Voglibose)
- Local Anesthetics (Structure & SAR): Benzocaine and related derivatives (Cocaine, Hexylcaine, Meprylcaine, Piperocaine), Aminobenzoic derivatives (Procaine, Benzocaine, Tetracaine), Anilide derivatives (Lignocaine, Prilocaine, Etidocaine), Miscellaneous (Phenacaine, Dibucaine)
SAR (Structure Activity Relationship)
Mechanisms and chemical classification