B.Pharm 5th Semester Medicinal Chemistry II – Unit 1 Notes

Medicinal Chemistry–II Unit 1 notes for B.Pharmacy 5th semester cover antihistaminic agents (H1 and H2 blockers), proton pump inhibitors, and antineoplastic drugs. The notes explain histamine receptors, chemical structures, mechanisms of action, SAR, synthesis, and therapeutic uses of antiulcer, anticancer, and antiallergic drugs for exam preparation.

Bachelor of Pharmacy
Semester		5th Semester		Subject		Medicinal Chemistry II
Syllabus
Unit 1st	Antihistaminic agents: Histamine, receptors and their distribution in the human body H1-antagonists: Diphenhydramine hydrochloride, Dimenhydrinate, Doxylamine succinate, Clemastine fumarate, Diphenylpyraline hydrochloride, Tripelennamine hydrochloride, Chlorcyclizine hydrochloride, Meclizine hydrochloride, Buclizine hydrochloride, Chlorpheniramine maleate, Triprolidine hydrochloride, Phenindamine tartrate, Promethazine hydrochloride, Trimeprazine tartrate, Cyproheptadine hydrochloride, Azatidine maleate, Astemizole, Loratadine, Cetirizine, Levocetirizine Cromolyn sodium H2-antagonists: cimetidine, famotidine, and ranitidine. Gastric proton pump inhibitors: Omeprazole, Lansoprazole, Rabeprazole, Pantoprazole Antineoplastic agents: Alkylating agents: Meclorethamine*, Cyclophosphamide, Melphalan, Chlorambucil, Busulfan, Thiotepa Antimetabolites: Mercaptopurine, Thioguanine, Fluorouracil, Floxuridine, Cytarabine, Methotrexate, Azathioprine Antibiotics: Dactinomycin, daunorubicin, doxorubicin, and bleomycin Plant products: Etoposide, vinblastine sulphate, vincristine sulphate Miscellaneous: Cisplatin, Mitotane.

Unit 1 focuses on antihistaminic, antiulcer, and antineoplastic agents. It explains histamine and its receptors, H₁ and H₂ antagonists, and proton pump inhibitors used in allergic and gastric disorders. The unit also covers major classes of anticancer drugs, including alkylating agents, antimetabolites, antibiotics, plant products, and miscellaneous agents, emphasizing their chemical structures, mechanisms of action, SAR, and therapeutic applications.

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