Medicinal Chemistry II is one of the important subjects in the B.Pharm 5th Semester. Unit 2 mainly deals with Anti-anginal Agents, Diuretics, and Anti-hypertensive Agents. Students must focus on classification, mechanism of action, structure–activity relationship (SAR), therapeutic uses, and synthesis of selected drugs as per PCI syllabus.
Unit 2 Syllabus – Medicinal Chemistry II
1. Anti-anginal Agents
- Vasodilators: Amyl nitrite, Nitroglycerin*, Pentaerythritol tetranitrate, Isosorbide dinitrite*, Dipyridamole.
- Calcium Channel Blockers (CCBs): Verapamil, Bepridil hydrochloride, Diltiazem hydrochloride, Nifedipine, Amlodipine, Felodipine, Nicardipine, Nimodipine.
2. Diuretics
- Carbonic Anhydrase Inhibitors: Acetazolamide*, Methazolamide, Dichlorphenamide.
- Thiazides: Chlorthiazide*, Hydrochlorothiazide, Hydroflumethiazide, Cyclothiazide.
- Loop Diuretics: Furosemide*, Bumetanide, Ethacrynic acid.
- Potassium-sparing Diuretics: Spironolactone, Triamterene, Amiloride.
- Osmotic Diuretics: Mannitol.
3. Anti-hypertensive Agents
- Timolol, Captopril, Lisinopril, Enalapril, Benazepril hydrochloride, Quinapril hydrochloride,
- Methyldopate hydrochloride*, Clonidine hydrochloride, Guanethidine monosulphate, Guanabenz acetate,
- Sodium nitroprusside, Diazoxide, Minoxidil, Reserpine, Hydralazine hydrochloride.
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🔑 Important Points for Students
- Drugs marked with * are compulsory for chemical synthesis.
- Focus areas: Classification, Mechanism of Action, SAR, Synthesis, and Therapeutic Uses.
- Learn structural modifications in diuretics and ACE inhibitors.
- Remember adverse effects of nitrates, thiazides, and beta-blockers.
- Prepare short notes on SAR of CCBs and thiazides.
- Practice reaction mechanisms for synthesis-based drugs.
- Very useful for GPAT, Drug Inspector, and Pharma Competitive Exams.
Medicinal Chemistry II (B.Pharm 5th Semester) focuses on drug chemistry, structure–activity relationships, and mechanisms of important therapeutic agents. Unit 2 covers three major drug categories – Anti-anginal agents, Diuretics, and Anti-hypertensive agents. This unit is very important for university exams, GPAT, and NIPER preparation.
A PDF version from the University curriculum outlines the same content and emphasizes studying classification, mechanism of action, therapeutic uses, structure-activity relationships, and the chemical synthesis of selected drugs (marked with ‘*’) within Unit II