Medicinal Chemistry–II Unit 2 notes for B.Pharmacy 5th semester cover anti-anginal drugs, diuretics, and antihypertensive agents. Topics include nitrates, calcium channel blockers, ACE inhibitors, beta blockers, vasodilators, and all classes of diuretics. The notes explain chemical structures, mechanisms of action, SAR, synthesis, and therapeutic applications for exam preparation.
Medicinal Chemistry Unit 2 Overview
| Bachelor of Pharmacy | |||||||
| Semester | 5th Semester | Subject | Medicinal Chemistry II | ||||
| Syllabus | |||||||
| Unit 2nd | Anti-anginal: Vasodilators: Amyl nitrite, nitroglycerin, pentaerythritol tetranitrate, isosorbide dinitrite, dipyridamole. Calcium channel blockers: Verapamil, Bepridil hydrochloride, Diltiazem hydrochloride, nifedipine, amlodipine, felodipine, nicardipine, and nimodipine. Diuretics: Carbonic anhydrase inhibitors: acetazolamide, methazolamide, and dichlorphenamide. Thiazides: Chlorthiazide, Hydrochlorothiazide, Hydroflumethiazide, Cyclothiazide, Loop diuretics: Furosemide,Bumetanide, Ethacrynicacid. Potassium sparing Diuretics: Spironolactone, Triamterene, Amiloride. Osmotic Diuretics: Mannitol Anti-hypertensive Agents: Timolol, Captopril, Lisinopril, Enalapril, Benazepril hydrochloride, Quinapril hydrochloride, Methyldopate hydrochloride, Clonidine hydrochloride, Guanethidine monosulphate, Guanabenz acetate, Sodium nitroprusside, Diazoxide, Minoxidil, Reserpine, Hydralazine hydrochloride. | ||||||
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Unit Summary
Unit 2 covers drugs used in cardiovascular disorders, including anti-anginal agents, diuretics, and antihypertensive drugs. It explains nitrates and calcium channel blockers for angina management, various classes of diuretics acting on different parts of the nephron, and antihypertensive agents such as ACE inhibitors, beta blockers, centrally acting drugs, and vasodilators. The unit emphasizes chemical structures, mechanisms of action, SAR, and therapeutic uses.
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