B.Pharmacy 3rd Semester Pharmaceutical Organic Chemistry – 2 notes are available of units 1st to 5th an handwriting
Unit 1
Benzene and its derivatives
- Analytical, synthetic and other evidences in the derivation of structure of benzene, Orbital picture, resonance in benzene, aromatic characters, Huckel’s rule
- Reactions of benzene – nitration, sulphonation, halogenationreactivity, Friedelcrafts alkylation- reactivity, limitations, Friedelcrafts acylation.
- Substituents, effect of substituents on reactivity and orientation of mono substituted benzene compounds towards electrophilic substitution reaction
- Structure and uses of DDT, Saccharin, BHC and Chloramine
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Nirali Parkashan
Unit 2
Phenol* – Acidity of phenols, effect of substituents on acidity, qualitative tests, Structure and uses of phenol, cresols, resorcinol, naphthols
Aromatic Amines* – Basicity of amines, effect of substituents on basicity, and synthetic uses of aryl diazonium salts
Aromatic Acids* – Acidity, effect of substituents on acidity and important reactions of benzoic acid.
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Unit 3
Fats and Oils
- Fatty acids – reactions.
- Hydrolysis, Hydrogenation, Saponification and Rancidity of oils, Drying oils.
- Analytical constants – Acid value, Saponification value, Ester value, Iodine value, Acetyl value, Reichert Meissl (RM) value – significance and principle involved in their determination.
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Unit 4
Polynuclear hydrocarbons:
- Synthesis, reactions
- Structure and medicinal uses of Naphthalene, Phenanthrene, Anthracene, Diphenylmethane, Triphenylmethane and their derivatives
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Unit 5
Cyclo alkanes*
Stabilities – Baeyer’s strain theory, limitation of Baeyer’s strain theory, Coulson and Moffitt’s modification, Sachse Mohr’s theory (Theory of strainless rings), reactions of cyclopropane and cyclobutane only
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