B.Pharmacy 6th Semester Medicinal Chemistry-III notes covering antibiotics, antimalarials, antitubercular, antiviral, antifungal drugs, sulphonamides, drug design, QSAR, SAR, synthesis, and mechanisms of action. Well-structured, exam-oriented notes ideal for concept clarity, quick revision, and university exam preparation.
Medicinal Chemistry Overview
| Bachelor of Pharmacy | |||||||
| Semester | 6th Semester | Subject | Medicinal Chemistry-3 | ||||
| Syllabus | |||||||
| Unit 1st | Antibiotics Historical background, Nomenclature, Stereochemistry, Structure activity relationship, Chemical degradation classification and important products of the following classes. β-Lactam antibiotics: Penicillin, cephalosporins, β-lactamase inhibitors, Monobactams Aminoglycosides: Streptomycin, Neomycin, Kanamycin Tetracyclines: Tetracycline, Oxytetracycline, Chlortetracycline, Minocycline, Doxycycline | ||||||
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| Unit 2nd | Antibiotics Historical background, Nomenclature, Stereochemistry, Structure activity relationship, Chemical degradation classification and important products of the following classes Macrolide: Erythromycin Clarithromycin, Azithromycin. Miscellaneous: Chloramphenicol, Clindamycin. Prodrugs: Basic concepts and application of prodrugs design. Antimalarials: Etiology of malaria. Quinolines: SAR, Quinine sulphate, Chloroquine, Amodiaquine, Primaquine phosphate, Pamaquine*, Quinacrine hydrochloride, Mefloquine. Biguanides and dihydrotriazines: Cycloguanil pamoate, Proguanil. Miscellaneous: Pyrimethamine, Artesunete, Artemether, Atovoquone | ||||||
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| Unit 3rd | Anti-tubercular Agents Synthetic anti tubercular agents: Isoniozid, Ethionamide, Ethambutol, Pyrazinamide, Para amino salicylic acid. Anti tubercular antibiotics: Rifampicin, Rifabutin, Cycloserine Streptomycine, Capreomycin sulphate. Urinary tract anti-infective agents Quinolones: SAR of quinolones, Nalidixic Acid,Norfloxacin, Enoxacin, Ciprofloxacin, Ofloxacin, Lomefloxacin, Sparfloxacin, Moxifloxacin Miscellaneous: Furazolidine, Nitrofurantoin, Methanamine. Antiviral agents: Amantadine hydrochloride, Rimantadine hydrochloride, Idoxuridine trifluoride, Acyclovir*, Gancyclovir, Zidovudine, Didanosine, Zalcitabine, Lamivudine, Loviride, Delavirding, Ribavirin, Saquinavir, Indinavir, Ritonavir. | ||||||
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| Unit 4th | Antifungal agents: Antifungal antibiotics: Amphotericin-B, Nystatin, Natamycin, Griseofulvin. Synthetic Antifungal agents: Clotrimazole, Econazole, Butoconazole, Oxiconazole Tioconozole, Miconazole, Ketoconazole, Terconazole, Itraconazole, Fluconazole, Naftifine hydrochloride, Tolnaftate. Anti-protozoal Agents: Metronidazole, Tinidazole, Ornidazole, Diloxanide, Iodoquinol, Pentamidine Isethionate, Atovaquone, Eflornithine. Anthelmintics: Diethylcarbamazine citrate, Thiabendazole, Mebendazole*, Albendazole, Niclosamide, Oxamniquine, Praziquantal, Ivermectin Sulphonamides and Sulfones Historical development, chemistry, classification and SAR of Sulfonamides: Sulphamethizole, Sulfisoxazole, Sulphapyridine, Sulphamethizine, Sulfacetamide, Sulfamethoxaole, Sulphadiazine, Mefenide acetate, Sulfasalazine. Folate reductase inhibitors: Trimethoprim, Cotrimoxazole. Sulfones: Dapsone | ||||||
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| Unit 5th | Introduction to Drug Design Various approaches used in drug design. Physicochemical parameters used in quantitative structure activity relationship (QSAR) such as partition coefficient, Hammet’s electronic parameter, Tafts steric parameter and Hansch analysis. Pharmacophore modeling and docking techniques. Combinatorial Chemistry: Concept and applications of combinatorial chemistry: solid phase and solution phase synthesis. | ||||||
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Unit Summary
These B.Pharmacy 6th Semester Medicinal Chemistry-III notes are designed to support strong conceptual understanding and effective exam preparation. The syllabus includes antibiotics such as β-lactams, aminoglycosides, tetracyclines, and macrolides with emphasis on SAR, stereochemistry, degradation, and mechanisms of action. Antimalarial, anti-tubercular, antiviral, antifungal, antiprotozoal, anthelmintic, sulphonamide, and quinolone drugs are explained in a systematic and student-friendly manner. The final unit introduces modern drug design approaches including QSAR parameters, pharmacophore modeling, docking techniques, and combinatorial chemistry. These notes are ideal for B.Pharm students looking for clear explanations, structured content, and reliable material for exams and quick revision.
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