B Pharmacy 6th Semester Biopharmaceutics and Pharmacokinetics Notes

B.Pharmacy 6th Semester Biopharmaceutics and Pharmacokinetics notes covering drug absorption, distribution, metabolism, excretion, bioavailability, bioequivalence, compartment models, multiple dosing, and nonlinear pharmacokinetics. Well-structured, exam-oriented notes ideal for concept clarity, numerical problem solving, and university exam preparation.

Bachelor of Pharmacy
Semester		6th Semester		Subject		Biopharmaceutics and Pharmacokinetics
Syllabus
Unit 1st	Introduction to Biopharmaceutics Absorption: Mechanisms of drug absorption through GIT, factors influencing drug absorption though GIT, absorption of drug from Non per oral extra-vascular routes, Distribution Tissue permeability of drugs, binding of drugs, apparent, volume of drug distribution, plasma and tissue protein binding of drugs, factors affecting protein-drug binding. Kinetics of protein binding, Clinical significance of protein binding of drugs
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Unit 2nd

Elimination: Drug metabolism and basic understanding metabolic pathways renal excretion of drugs, factors affecting renal excretion of drugs, renal clearance, non-renal routes of drug excretion of drugs Bioavailability and Bioequivalence: Definition and Objectives of bioavailability, absolute and relative bioavailability, measurement of bioavailability, in-vitro drug dissolution models, in-vitro-in-vivo correlations, bioequivalence studies, methods to enhance the dissolution rates and bioavailability of poorly soluble drugs.

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Unit 3rd

Pharmacokinetics: Definition and introduction to Pharmacokinetics, Compartment models, Non compartment models, physiological models, One compartment open model. (a) Intravenous Injection (Bolus) (b) Intravenous infusion and (c) Extravascular administrations. Pharmacokinetic parameters – KE, t1/2, Vd, AUC, Ka, Clt and CLR- definitions methods of eliminations, understanding of their significance and application

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Unit 4th	Multicompartment models: Two compartment open model. IV bolus Kinetics of multiple dosing, steady state drug levels, calculation of loading and mainetnance doses and their significance in clinical settins.
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Unit 5th	Nonlinear Pharmacokinetics: a. Introduction, b. Factors causing Non-linearity. c. Michaelis-menton method of estimating parameters, Explanation with example of drugs.
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These B.Pharmacy 6th Semester Biopharmaceutics and Pharmacokinetics notes are prepared to provide a strong foundation in drug absorption and disposition principles. Unit I explains biopharmaceutics, mechanisms of drug absorption through GIT and non-oral routes, drug distribution, protein binding, volume of distribution, and their clinical significance.

Unit II focuses on drug elimination, metabolism pathways, renal and non-renal excretion, bioavailability, bioequivalence, in-vitro dissolution models, IVIVC, and strategies to enhance bioavailability of poorly soluble drugs. Unit III covers pharmacokinetics concepts including compartment and non-compartment models, one-compartment models for IV bolus, infusion, and extravascular dosing, along with key pharmacokinetic parameters. Unit IV explains two-compartment models, multiple dosing, steady-state levels, and dose calculations. Unit V introduces nonlinear pharmacokinetics and Michaelis–Menten kinetics. These notes are ideal for revision, numericals, and exam success.

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